Astavalence

Neural signalling

Action potential and myelin

A labelled mechanism map shows where physiology fails when disease is selected.

-70 mVresting membrane

What to noticeLabels are deliberately explicit: ions, channels, antibodies, pumps, vessels and pressure compartments are visible.

Disease modifier

Normal physiology

Choose a disease state and the diagram will reveal the precise failing component.

Choose normal or abnormal

55%

Stimulus strength

Mechanistic equation

Vm depends on ion conductance and electrochemical gradients.

Clinical reasoning check

Why does demyelination slow conduction?

Myelin increases membrane resistance and reduces capacitance, so current spreads rapidly to the next node. Demyelination leaks current and can reduce the safety factor below propagation threshold.

Educational simulation, not a diagnostic tool.