Astavalence

PathoSchema® by Astavalence · Inherited Liver Disease Simulator

PathoSchema® by Astavalence

Inherited Liver Disease Simulator

Hereditary haemochromatosis with multisystem iron overload

Choose the disorder

Compare the major inherited liver diseases and watch the liver and extrahepatic organs light up together

HH autosomal recessive

Disease severity Moderate multisystem involvement

Current mechanism

Low hepcidin causes excessive intestinal iron absorption. Iron progressively deposits in hepatocytes and multiple extrahepatic organs.

What you are seeing

The body map highlights both liver pathology and the dominant extrahepatic manifestations. Increase severity to watch multisystem involvement intensify.

Disease load

II model

Current disease

Hereditary haemochromatosis

Core mechanism. Low hepcidin signalling causes uncontrolled iron absorption, parenchymal iron overload, fibrosis and extrahepatic end organ injury.

Liver manifestations

Extrahepatic manifestations

Investigations

Hotspot focus

Management priorities

Exam pearls

Reset

Start with moderate disease. Compare how the same liver centred problem becomes neurologic, cardiopulmonary, renal, skeletal or dermatologic depending on the gene defect.

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