Astavalence

PathoSchema by Astavalence · Pancreas Physiology Simulator

Pancreas map The pancreas has two jobs: enzymes and bicarbonate enter the gut; hormones enter the blood.

Current mechanism

Pancreas overview

Head in the duodenal C-loop, body crossing the midline, tail toward the spleen. Exocrine secretions drain into the duodenum. Endocrine hormones drain into blood.

Meal load60% Blood glucose signal55%

Particle code

Acid chymestomach to duodenum

CCKenzyme signal

Secretinbicarbonate signal

Enzymesacinar output

Bicarbonateduct output

Insulinfed state

Glucagonfasting state

What to read from the picture

Clinical reasoning

Mechanism note

Select a function to see whether the pancreas is sending substances into the gut, sending hormones into blood, or failing through premature enzyme activation, fibrosis, obstruction or endocrine loss.

Failure state checklist

Acute pancreatitisenzyme activation inside pancreas

Chronic pancreatitisfibrosis, duct damage, calcification

Exocrine insufficiencyfat malabsorption, steatorrhoea

Endocrine failurediabetes and hypoglycaemia risk

Rule: gut outputs explain digestion; blood outputs explain glucose control.

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